Winfrey told the audience that she loved "The Oprah Winfrey Show," that it had been her life and that she knew when it was time to say goodbye. "Twenty-five years feels right in my bones and feels right in my spirit," she said.

Winfrey talked about being nervous when the program began in 1986, and thanked audiences who had invited her into their homes over the past two decades. "I certainly never could have imagined the yellow brick road of blessings that would have led me to this moment," she said.

The powerhouse show became the foundation for her multibillion-dollar media empire, but in the last year, has seen its ratings slip 7 percent. Winfrey, 55, is widely expected to start up a new talk show on OWN: The Oprah Winfrey Network, a much-delayed joint venture with Discovery Communications Inc. that is projected to debut in 2011. OWN is to replace the Discovery Health Channel and will debut in some 74 million homes.

Winfrey said she and her staff were going to brainstorm ideas for the final season of "The Oprah Winfrey Show" and that she hoped viewers would take "this 18-month ride with me."